BIOC39H3 Lecture 9: Copy of BIOC39 - Lecture 9 Notes
12 May 2020
School
Department
Course
Professor
Document Summary
Mucosal immunology (not included replaced by dr. krammer"s lecture) Waldeyer"s ring protects entry to gut and airway. The systemic and mucosal immune systems use different strategies. Inflammatory capacity in reduced in intestinal macrophages: the capacity for cytokine production in intestinal macrophages is limited and their presentation of antigen and co-stimulation is reduced, so, these macrophages are there to deal with the pathogen. M cells are specialized to transport microorganisms to galt: do not secrete digestive enzymes or mucus, lack glycocalyx. In endothelial cells this acts as a shield to prevent pathogens from penetrating through it. In contrast to endothelial cells which are secreting enzymes for digesting/break down food, and secreting mucus, these m cells don"t do either. Lamina propria is populated with effector leukocytes in healthy individuals. Induction of gut-homing receptors and integrin"s is under control of intestinal dcs: relevance to vaccination strategies. Secretory iga van bind pathogens in several locations.
