BIOC34H3 Lecture Notes - Lecture 7: Third-Degree Atrioventricular Block, Heart Valve, Hypertension

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29 May 2019
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Heart failure can be shown on a starling curve which plots sv as a function of edv. It shows that heart failure causes a reduction in sv at any given edv. This can be partially offset by sympathetic stimulation which can enhance ventricular contractility (thereby increasing sv) and can also increase heart rate. Increases in sv and hr lead to increases in co. It takes a smaller edv to achieve a normal sv when sympathetic stimulation (purple) is added to a failing heart (red) although it doesn"t bring sv all the way back to the level in a normal heart (green). One of the most common causes of heart failure is myocardial infarction (heart attack). This happens when cardiac myocytes die due to a blockage of the coronary arteries. The blockages can be a result of fatty deposits or plaque, and begin to show effects as ischemia, or reduced blood flow.

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