BIOC19H3 Lecture Notes - Lecture 4: Chromosome, Locus Control Region, Cell Surface Receptor
Document Summary
Lecture objectives: development of blood cells, dev. of erthryocytes, globin gene expression, role of erythropoietin (epo, rbc differentiation. Development of blood cells: hematopoiesis: formation of blood cells (all of them, not just rbc) Is a miniature developmental system-one type of cell gives rise to a number of diff cells. Leukemia patients get rid of their bone marrow and get donated new ones. Originate from the mesoderm in the yolk sac blood islands of an early embryo. Express a large number of tf, membrane associated protiens, signaling moelcules. The large amount of tf tell you there is a lot of dna regulation occurring. The large amount of memebrane associated proteins tell you that they are responding to a lot of specific signals. Yolk sac in human embryos: very clearly extra-embryonic structure (right outside the embryo, in mammals, functions as the circulatory system of the fetus.
