BIOC17H3 Lecture Notes - Lecture 7: Cell Wall, Primary Transcript, Intron
Document Summary
Lecture 7: comparing and contrasting prokaryotes and eukaryotes; the. Is it similar to eukaryotes: similar, have more than one pathway, very complex, some bacteria use multiple depending on conditions, different secretory pathways do different things. Gram-positive: hydrophilic, so need very few porins, periplasm, nutrients are broken down here, enzymes attached to plasma membrane synthesize peptidoglycan, plasma membrane contains the chemotaxis system. Inner leaflet: lpr (lipoproteins) and phospholipids: porins, peptidoglycan loosely associated with the inner leaflet. Gram-negative vs. gram-positive: gram-positive has teichoic acid that gram-negative don"t, gram-negative has lps and lpr that gram-positive doesn"t. Cell wall: gives shapes, structure, and protection, beta-lactam antibiotics attack cell wall creation (peptidoglycan synthesis), causes lysis, cell wall can contribute to pathogenicity (in terms of adhesiveness, contain receptor sites for certain bacteriophages, determines staining characteristics. Immunogenicity (antigenicity: cells make antibodies, antibodies against bacterial wall cell antigens can inhibit bacterial adherence. Innate requires no prior exposure to an organism.
