BIOC14H3 Lecture Notes - Lecture 4: Phenylketonuria, Connectome, Krabbe Disease

• School: UTSC
• Department: Biological Sciences
• Course: BIOC14H3
• Professor: Patrick Mc Gowan

Document Summary

Lecture 4 objectives: quantitative trait locus (qtl, qtl contribution to quantitative traits, studying qtls, qtl mapping in lab animals, distribution of quantitative traits, gene-environment interaction, evolution of traits, natural & sexual selection. Inclusive fitness: genetic diversity, environmental effects on genetics and behavior, prenatal environmental effects, fas, cah, ais. More contributing genes = higher probability of developing obesity. Infinite number of loci model: arranging the genotype in order of contributing gene number (cid:198) normal distribution curve (bell curve, highest frequency in the middle, lowest frequency on each end. Distribution of birth weight: normal distribution is very common in nature. Linkage vs association studies: both types of analysis have their advantages and disadvantages. See: disease susceptibility advantage and disadvantages of linkage studies. See: disease susceptibility advantage and disadvantages of gene association studies. Identify loci that show high probability of being associated with the trait (p-value) Cross the two parental strains (cid:198) f1 (first filial generation) individuals.