BIOC13H3 Lecture Notes - Lecture 3: Casein Kinase 2, Protein Phosphatase 1, Glycogen Synthase
Document Summary
Lecture 3 topic 3b glycogen, gluconeogenesis, and pentose phosphate (june 8. 5: at the end of last week"s lecture, we spoke about the three major reactions involved in the synthesis of the straight-chain portions of glycogen. Glycogen synthesis regulation of glycogen synthase: glycogen synthase catalyzes the conversion of the glucosyl (glc) moiety of uridine diphosphate glucose (udp-glc) into glucose to be incorporated into glycogen via an (1 4) glycosidic bond. Bottom arrow : moving from gsb to gsa, the protein that does this is pp1 (generic protein phosphatase, insulin is a stimulant of pp1 (this makes sense, being an inhibitor of. 21 this kind of phosphorylation is called a silent phosphorylation as the conventional phosphorylation of an enzyme does have an observable impact on its activity. Priming site on glycogen synthase is phosphorylated by ckii, attracting gsk3. Gsk hops through the glycogen synthase until phosphate groups are added to the.
