BIOB51H3 Lecture Notes - Lecture 10: Allele Frequency, Genotype Frequency, Statistical Power
1 Mar 2016
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Biob51 lec 10 mutation and selection: mutation and selection. Allele increases in frequency: very beneficial, may spread to fixation, evolutionary change. Allele lost: very deleterious, may be lost in 1 generation. Will not appear in population level frequency at all. Single cell of e. coli (mutation: coli strain = no recombination, no variation thru sexual reproduction (mutation) Nutrient limited medium (not all of them will get the get the nutrients they need to survive: mutation and selection, selection, competition for resources. 5 x 106 cells (randomly chosen) (1 day, 7 generations) Notice pattern: periods without change, change occurs in jumps (x 12) They chose a large sample instead of a single individual for statistical power, to better represent the original population, and to mimic natural selection. Compare to c. elegans experiment: mutation and selection line had a flat response, mutation only had a steadily declining response, c. elegans study was not as long as this one (only 250 generations vs.
