BIOB51H3 Lecture Notes - Lecture 12: Hemoglobin, Asian Americans, Sickle-Cell Disease

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One allele favoured (directional selection): a study was conducted with flour beetles and directional selection. In this stimulation, if you started at 50% of the lethal recessive allele, h-w shows that there is a rapid loss of the lethal allele. However, as the frequency of the allele goes to 10%, the loss begins to occur at a slower pace. Point mutations and pain: point mutation is autosomal recessive in scn9a gene, which causes an inability to feel pain. Hypothesis: s allele is favoured by heterozygote superiority: prediction 1: the frequency of ss will be highest where malaria is the most prevalent, data: ss is more common in environments where the frequency of malaria is high. South america, southern europe (when compared to individuals from. Northern europe: looking at the incidence rate per 10,000 births, sickle cell in anemia in. West africans is 200, while it is 0. 5 in the uk.

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