BIOB11H3 Lecture Notes - Lecture 20: Telomerase, Ploidy, Growth Factor
Document Summary
Normal cells rely on density of surrounding population of cells in order to reproduce. When normal cells make contact with neighbouring cells, the cell cycle arrests and also keeps cells from growing beyond its monolayer. >cancer cells don"t do this so they proliferate continuously piling up on each other. Normal cells are anchored by substrate, keeping them in place. Growth factors regulate cell growth, if not present, cell will not continue to grow. >cancer cells produce its own, they produce their own growth factors. >aneuploids are common among cancer cells, results in apoptotic failure. Break down ecm, controlled secretion in normal cells. >cancer cells excrete elevated levels to loosens tissue so they can detach and invade adjacent tissues (metastasize) *normal cells have nite # of divisions, and are regulated. *cancerous cells become immortalized since these process are mutated. Unresponsive to growth controls but lack the ability to invade other tissues (ex.
