BIOB11H3 Lecture 23: BIOB11 Lecture 23
Document Summary
Lecture 23 signal transduction iii: second messenger and receptor tyrosine kinase signaling. Second messenger molecules that relay signals received at receptors on the cell surface to target molecules in the cytosol and/or nucleus. Ca2+ induced ca2+ release a process where calcium is able to activate calcium release from intracellular ca2+ stores; crucial for excitation- contraction coupling in cardiac muscle. Guard cell surround each stoma and regulate the rate of transpiration by opening and closing the stomata. Receptor tyrosine kinases high-affinity cell surface receptors for polypeptide growth factors, cytokines, and hormones. Autophosphorylation type of post-translational modification of proteins; phosphorylation of the kinase by itself. Insulin receptor transmembrane receptor activated by insulin, igf-i, Igf-ii and belongs to a class of tyrosine kinase receptors; role in regulation of glucose homeostasis. Diabetes metabolic disease in which there are high blood sugar levels over a prolonged period. 15. 4 protein-tyrosine phosphorylation as a mechanism for signal.
