BIOB10H3 Lecture Notes - Lecture 11: Mitochondrion, Focal Adhesion, Connection Form
9 Dec 2017
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Document Summary
The extracellular matrix surrounds the cells everything outside the cell interact beyond the pm but can interact with the pm proteins. Ecm function: support to cells give cells identity sites of cell attachment generates signals regulate cell function. Ecm composition: mesh of extended brous proteins secreted by exocytosis inside the cell, very compact ; outside the cell (ecm) not as compact larger molecule - brous protein better than compact. Glycosaminoglycans (gags) formed by 2 di erent sugars contain a lot of sulphate groups = negative charge. One very large gag is hyaluronic acid can hold on to lots and lots of gag. Gag that holds other gags resist crushing forces. Collagens and proteoglycans together provide strength and resistance to deformation. 2 non identical polypeptides joined by disulphide bonds some bronectin domains can bind the cell bind cell surface proteins that are connected to the cytoskeleton other domains can bind ecm components.
