BIOB10H3 Lecture Notes - Lecture 7: Heteroplasmy, Atp Synthase, Pyruvic Acid
9 Dec 2017
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Lecture 7: mitochondria takes up over 20% of the cells volume arose from prokaryotes, mitochondria can divide within the cell = binary ssion induced by contact with thin tubules from the er. ~50% protein : ~50% lipid ratio protein channels - porins beta pleated sheets can allow passage of large number of molecules respond to conditions within the cell. Inner mitochondrial membrane (imm) cristae - thin folds. ~75% protein : ~25% lipid ratio almost 100 di erent proteins present selective rich in phospholipid called cardiolipin also found on many bacterial membranes - supports the bacterial origin of the mitochondria. high concentration of proteins contains its own dna and ribosomes encodes ~37 genes. Mitochondria requires 1000s of proteins for normal function. Proteins are imported into the mitochondria via post- translational import of proteins they require signals: matrix proteins, mitochondrial presequence at the n terminus of proteins composed of several positively charged residues.
