BIOB10H3 Lecture Notes - Lecture 4: Lysosome, Cell Membrane, Peroxisome
Document Summary
The glucose attached to the oligosaccharides are those that allow the newly synthesized protein in the rer. It gives of wrong signals, inappropriate interactions, and also makes up protein aggregate. The chaperone calnexin function in the protein quality control. Calnexin reinforces proper folding of the protein. The chaperone protein clips off when the excess glucose is clipped off from the glucose being synthesized. Incorrect folding of the protein results in reglycosylated of the protein. Any protein my go several rounds to form a properly formed protein. Cells have a plan called unfolded protein responses (upr) Erad is involved in small misfolding of the protein that is manageable while the upr are involved with large stress caused by clumps of protein misfolded and unfolded. Upr relieves the stress of the er caused by the misfolded and unfolded protein. Bip binds to the misfolded proteins after moving from the rer receptor. (bip is a chaperone)
