BIOA01H3 Lecture Notes - Lecture 34: Transfer Rna, Phenylalanine, Peptide
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BIOA01H3 Full Course Notes
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Central dogma: form dna to rna to protein. 61 diff. sense codons do not require 61 diff. trnas. First 2 nucleotides of anticodon and codon must match exactly. Initiation: ribosomes assembled together with mrna molecule and initiator methinonine-trna. Elongation: addind amino acids one by one, Termination: the stop codons make everything fall apart. Complex binds to 5 cap of mrna and scans until it finds the start codon. Large ribosomal subunit binds to complete initiation: gdp is used for signal that the job is finished. Trna matching the next codon enters a site. Enzyme activity joins meth to trna #2: ribosome is read 5-3. Termination: begins when a site reaches stop codon (uga, uag, uaa) 2: release factor (rf) of termination factor binds to a site, so the peptide is release from the final trna, remaining parts of complex separate free to go find another cap to translate.
