BIOA01H3 Lecture Notes - Lecture 6: Rna Polymerase Ii, Nuclear Membrane, Polymerization
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Genetic information in dna directs the activities in a cell. The central dogma: the flow of information is from dna mrna the synthesis of proteins. Many exceptions: the flow of information between proteins (i. e. Protein provides structure and carries out many essential functions in a cell. Readi(cid:374)g of the te(cid:373)plate stra(cid:374)d is (cid:1007)" to 5". Buildi(cid:374)g of rna tra(cid:374)s(cid:272)ript is 5" to (cid:1007)". Transcription starts at the promoter sequence and ends at the terminator sequence. The tra(cid:374)s(cid:272)ript is read i(cid:374) the 5" to (cid:1007)" direction. At the promoter, the rna polymerase and associated proteins bind to the dna duplex (double stranded dna. Which strand is transcribed differs depending on the gene. Many eukaryotic promoters contain a sequence similar to tataaa, which is known as a tata box. The tata box shows us the location of the recognition of many protein factors that signals a start site for transcription a little downstream.