BIOA01H3 Lecture Notes - Lecture 5: Internal Ribosome Entry Site, Signal Recognition Particle, Chromatin Remodeling
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BIOA01H3 Full Course Notes
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Scans to aug which allows factors to leave and recruit large subunit so u have components of translation: dependent translation of most host proteins in the cell, ribosomes and translation initiation factors start scanning from the. 5" methyl cap to find aug where protein synthesis begins: poliovirus (paralysis) eif-4g protein chops up the protein needed for this scanning from the cap = no translation of capped mrnas = Cell shuts down protein production and only produces poliovirus proteins: poliovirus uses chopped eif-4g and assembles many host factors recruits small subunit and assemble ires, to 5" cap allowing to trans late proteins . Can be modified by methyl or acetyl groups. Can lead to more compression or loosens nucleosomes so u have accessible. Dna to translation: histone tail modifications, pattern of modification = histone code = affects chromatin structure and gene transcription, methylation of dna, promoter controls gene expression, under-methylation of cpg (p stands for phosphate linkage between.
