CHM362H5 Lecture Notes - Lecture 19: Acetyl-Coa, Oxidative Phosphorylation, Metabolic Pathway
Document Summary
Tricarboxylic acid cycle: also known as the citric acid cycle or krebs cycle, pyruvate acetyl-coa co2, metabolic pathway between glycolysis and electron-transport pathway that leads to oxidative phosphorylation (of adp, occurs in mitocondrial matrix. Fate of carbon in tca cycle: carbon atoms enter tca cycle as acetate units on acetyl-coa & are oxidized to co2. Reaction 0: pyruvate acetyl-coa: glycolysis occurs in the cytoplasm; the tca cycle occurs in the mitochondrial matrix, pyruvate diffuses across the outer membrane of the mitochondrion and then is. Pumped across the inner membrane into the matrix: pyruvate dehydrogenase complex catalyzes the oxidative decarboxylation of pyruvate. Link connecting glycolysis to the tca cycle. Pyruvate + coa + nad+ acetyl-coa + co2 + nadh + h+ Pyruvate dehydrogenase complex composition: multiple copies of three enzymes that are non-covalently associated. 30 2 2 heterotetramers of pyruvate dehydrogenase (e1) Rate enhancement: minimize side reactions, exceptional control. 1. 1 formation of ylid form of tpp (e1)
