CHM333H5 Lecture Notes - Lecture 1: Myoglobin, Enzyme, Alkaline Phosphatase
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100s => use of gold for treatment of old age in china => modern day use of sodium aurothiomalate for arthritis. 1493-1541 => theophastus bombastus von hohenheim (paracelcius: use of mercury oxides for treatment of syphilis, treatment of body as a biological unit. 1907s => use of pt for treatment of cancer (cisplatin or cis-pt(nh3)2cl2) Participation of inorganic elements in biological systems: by abundance, earth"s crust: o, si, al, fe, ca, sea: h, o, cl, na, mg, body: h, o, c, n, ca. Functions of metals in protein chemistry: transport, electrons. Siderophores (fe: oxygen => myoglobin (fe, copper => ceruloplasmin. Iron => ferritin (fe: structure maintenance, alkaline phosphatase (zn, alcohol dehydrogenase (zn, zn fingers (zn, catalysis, enzyme cofactors. Hydrolases: peptidases (zn, mg) and phosphatases (zn, mg, cu) Oxido-reductases: oxidases (fe, cu), reductases (fe, cu, mo), nitrogenases (fe, mo) Some can form clusters to facilitate multielectron processes. Most can assume coordination numbers greater than 4.
