PSY 3142 Lecture Notes - Lecture 16: Relapse Prevention, Khat, Asthma

• School: University of Ottawa
• Department: Psychology
• Course: PSY 3142
• Professor: Philip Wall

Document Summary

Some individual develop a pattern of cocaine binges, episodic bouts of repeated use lasting hours to days with little or no sleep. Other factors which contribute to transition of abuse: commodity with other psychiatric disorders, environmental cues and cocaine priming, incubation of cocaine craving (craving and release increase over time following withdrawal). Cocaine-dependent individuals show abnormal prefrontal cortical functioning manifested s de cits in inhibitory control and evaluating consequences of their behaviour. Pet imaging found increase da release in the dorsal stratum when dependent users are presented with cocaine-related stimuli. Da release is measured by da displacement of radio-labeled raclopride from d2 receptor. Longer periods of access to cocaine can lead to an escalation of intake that down-regulates the reward circuit. This makes cocaine less rewarding with time and encourages further increases in consumption. Secondary study: rats were allowed to self-administer cocaine for three months: high cocaine reinstatement (hrein, low cocaine reinstatement (lrein)