PHS 4300 Lecture Notes - Lecture 8: Upper Gastrointestinal Series, Hiatus Hernia, Gastric Mucosa

• School: University of Ottawa
• Department: Physiology
• Course: PHS 4300
• Professor: Joanne Savory

Document Summary

Inhibited by sympathetic ans as well as dehydration and drugs (antihistamines, antidepressants, radiations) causing xerostomia. B2/riboflavin needed to maintain mucosae or iron-deficient anemia, where opportunistic infection is likely to follow. Botox, ca blockers or balloon catheter to mechanically dilating ge sphincter. Barrett"s esophagus serious complication of gerd where lining of esophagus (stratified) changes morphology into that of lining of intestine (simple columnar epith. : as it changes, potential for error resulting in carcinoma. *gastric secretions are regulated 1) neutrally via long (vagus nerve) and short (enteric) reflexes and 2) hormonally via gastrin and histamine. *signals detect by ach (parasymph), gastrin (g-cells) and histamine (strongest) Esophageal varices esophageal varicose veins protrudes into the esophageal lumen; veins become thin walled and can rupture, ending in bleeding into the gi system (40% mortality: occurs bc of hepatic portal hypertension from cirrhosis. Aspirin, alcohol, bile salts = alteration in permeability in epithelium: aspirin also decreased mucous output in gi.