PHA 3112 Lecture Notes - Lecture 9: Rheumatoid Arthritis, Hyaline Cartilage, Nonsteroidal Anti-Inflammatory Drug
3 Apr 2019
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2nd generation: inhibit only cox and cox 2, unable to supress pain/inflammation without posing risk of serious gi side effects. 2, theoretically can supress pain and inflammation without increasing gi effects. Reye"s syndrome: rare but serious (25% mortality) childhood illness causing encephalophy, fatty liver degeneration. Causal link not established but should avoid nsaid use in children with flu, chickenpox. Tylenol safe to use but can blunt vaccine response. Nonaspirin 1st generation nsaids: reversibly inhibit cox 1 and cox 2, while aspirin is irreversible. Synovial inflammation leading to destruction of articular cartilage leading to direct contact between bones, eventually leading to bone fusion. Calcium physiology: functions include maintenance of bone structure, cns axonal excitability/transmitter release, muscle action, cv (myocardial/vascular contraction and blood coagulation). May autoimmune diseases: calcitonin-salmon: for paget"s disease, bisphosphonates: for osteoporosis, estrogens. Hypercalcemia: s/s include polyuria/dipsia, n/v/d, lethargy, depression, dysrhythmias. Caused by ca, hyperparathyroidism, vit d intoxication, thiazides.
