MIC 4124 Lecture Notes - Lecture 1: Gram-Negative Bacteria, Motility, Peptidoglycan
12 Apr 2020
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Document Summary
Grampositive singlemembrane thickammonia layerofpeptidoglycan a teichoicacidsprovide cellwallrigidity seem periplasmicspacecontains hydrolyticenzymes proteinsforprocessing uptake. Toxigenicityiabilitytoproaucetoxins virulencedegreemeasureofpathogenicity virulencefactorsbacterialproductthatcontributestovirulence nonpathogenic pathogenic commontypescontributestoadherenceinvasiveness. toxigenicity virulencegenesencodedonplasmidsor pathogenicityislands carriedbybacteriophage transposons. Chemicallysozymepsiadefensins i i i reactwispeciacreceptors ontargetcensiaitertheir activity dependent autocrineaffectcentnat releasecytokine paracrine. at. Inflammation localizedprotectiveresponse chemokinestypeofcytokine chemicalmediator recruitimmunecellsto siteotinfection thatdestroysblocksinjurious agentsinjuredtissue initiatedbycytokinessecreted byactivatedmacrophages macrophagerelease knemokines vasodilationcauserednesssiswening inflamcensimonocytesimigrateinto tissues"releasemediatorsthat causepain delivereffectorceuschemokine e"twiatoinfectedtissues tinsfiocalbloodciotiospreadinfect promoterepairdamagedtissue complementconsistserumproteinstormenzymatic system cascadetorinnateimmuneresponse proteinscircuarinactuesiactivated sequentiallyuponinsect. Antigenpresentingcenscapes capture processantigens displayviamtictoteenreceptors t providesignalsthatstimulateproliferation differentiationof tcells i edendriticcellsprocesssmanpeptidestpresentonsurface. I. id. aeaepreasme. ngteena secreted antibodies u neutralizephagocytosis ma ages r. insecea r. Sec dependentpathway atranslocatessubstratesacrosspriorpromoteintegrationintomembrane oproteinsofthispatnwayareunfoldedpreproteins win termsignal sea. recog. byseemachinery components secreatormsenamainpm secaarmcompiexwisecy a. atdependentmotorto translocatepreproteintnrucnanneiviaapnyarono. is se bindspreproteintokeepunaraedstate. Overview seeindependenttypesi proteinsaredirectly transiocardtromeynpiasmucenexterior is seadependenttypes iv iv proteinsarefirsttranslocatedacrosspm. Type c1355 singlestepprocess proteinsubstratewintermsignaiseg consist aoproteinstnatiormstrucuretodeliverestector proteinsfrombacterialcytoplasmdirectlyintohostcytoplasm onkainjectosomes fidget pm ftp tddinnostpm secretionottransiocatorproteins aoomootransiocatorproteinstormporeembeaded unaidedeffectorproteinsenterbaselbasa body passesthruneediertransiocator a. a. am a. atgfgporeintonosceu on m. 02stepprocess oproteinsubstratewinterminalsignalsea omostrequire autotransporiers proteins win termpassengerdomainin ctermtranslocatordomain extracemar on perimasm eye. Type vi thess singlestep composed bproteins resembleinvertedbacteriophagetail sheathcontractiondrivessystemthrutargetmembrane secreteeffectorproteinsineuerbaccentargets pathogenesis bacteria m ii atggrasgepmabhe. seieiir assemmeniii. App dnit. auncnse. eaffff sea preproxin coon seopathway sea a an.
