HSS 4102 Lecture Notes - Lecture 3: Apoptosis, Cpg Oligodeoxynucleotide, Neural Tube Defect

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 4102
• Professor: Ron Saulnier

Document Summary

Disruptions of ncrna function has been implicated in numerous disease conditions such as cancer, neurodegenerative disorders, cardiovascular diseases and aging. Epigenetic marks control the expression of genes that function in embryonic development, and other epigenetic programming events occur concurrently. Dna methylation marks, genetic imprinting, x- chromosome inactivation, the development of pluripotent stem cells, and the differentiation of somatic cells. Humans are exposed to hazards throughout their lifespan and the effects of these exposures are often not realized until decades later through either genetic or epigenetic modifications. During development, you must deprogram it before you reprogram it. Some genes stay programmed and you will get that gene from that parent. X-chromosome inactivation: through chromatin or histone acetylation chromosome is inactivated by being condensed (heterochromatin) so it can"t be transcribed. Pluripotent cells: less differentiated deprogramming it to a certain level where the cell can become different things from the original.