HSS 3305 Lecture Notes - Lecture 12: Angiotensin-Converting Enzyme, Angiotensin, Vasoconstriction
Document Summary
Blood ph shifts to acidic from an excess of h2co3. Blood ph shifts to basic from a decrease in h2co3. Classification of acid-base disturbances (2: metabolic: disturbance lies in bicarbonate member, metabolic acidosis: endogenous acid generated. Amount of acid generated exceeds body"s buffering capacity. Bicarbonate in plasma falls from being consumed in neutralizing excess acid. Compensation: by hyperventilation to lower pco2 and increased bicarbonate production in kidneys. Leads to retention of co2 and rise in h2co3. Compensation: bicarbonate production in kidneys: metabolic alkalosis: increased plasma bicarbonate. From loss of gastric juice, chloride depletion, excess corticosteroids, excess antacids. Body produces large amounts of acid from normal metabolic processes, such as breakdown of proteins and glucose or oxidation of fat. Regulatory mechanisms maintain ph range: 7. 38 to 7. 42: neutralize and eliminate the acids as soon as they are produced to maintain normal ph. Carbonic acid (h2co3): dissolved as co2 in plasma. Hyperventilation: lowers co2 and h2co3 in plasma.