HSS 3305 Lecture Notes - Lecture 8: T Helper Cell, Hiv-1 Protease, Viral Envelope

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 3305
• Professor: Karen Philips

Document Summary

Hiv= disease, aids= syndrome that occurs when the immune system collapses. M (major/main): subtypes a-d, f-h, j and k), 40 recombinant forms or crfs. Once inside: release: integrase, protease and reverse transcriptase, without stabilization of the receptors, it will cause a decreased infection rate, 95% of cd4+ t lymphocytes die after hiv infection do not produce viral particles. These cells are the innocent victims of the disease. It is pa(cid:396)t of the (cid:271)ody"s a(cid:374)ti(cid:373)i(cid:272)(cid:396)o(cid:271)ial (cid:396)espo(cid:374)se: apoptosis and necrosis. Includes swelling and lysis of the membrane, activates caspase 1 leading the production of inflammatory cytokines (different pathway), lysis of the cell membrane. Time course: first exposure: helper t cells damaged, monocytes are more resistant, devastates immune system. Cd4+ t cells: death due to disruption to cell membrane caused by release of new hiv viral particles, hijacking of cell processes by hiv prevents normal cell activity, impairs cell. Immune cells target hiv particles bound to cells, cell death.