HSS 2342 Lecture Notes - Lecture 31: Pyridoxal Phosphate, Pyruvate Carboxylase, Pantothenic Acid

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 2342
• Professor: Keir J Menzies

Document Summary

Lecture 11 chapter 10 nutrients for energy metabolism. Delivers activated carbon dioxide: tca cycle, formation of oxaloacetate, biotin is also involved in gluconeogenesis, fatty acid synthesis, and the breakdown of certain fatty acids and amino acids. Recommendations: limited research, no rda, ai (cid:894)ade(cid:395)uate i(cid:374)take (cid:396)athe(cid:396) tha(cid:374) reco(cid:373)(cid:373)e(cid:374)ded dieta(cid:396)y allowa(cid:374)ce(cid:895) No ul, no adverse effects have been observed with high intakes. Pyruvate carboxylase, an atp and biotin dependent enzyme fixes carbon dioxide into pyruvate. Part of coenzyme a (coa: tca cycle. Is involved in more than 100 different steps in the synthesis of lipids, neurotransmitters, steroid hormones, and hemoglobin. Recommendations: to prevent daily losses, ai. Many food sources: beef, poultry, whole grains, potatoes, tomatoes, and broccoli. Losses of pantothenic acid can be substantial because it is readily destroyed by freezing, canning, and refining processes. Three forms: pyridoxal, pyridoxine, pyridoxamine: all converted to coenzyme pyridoxal phosphate (plp)