HSS 2342 Lecture Notes - Lecture 25: Citric Acid Cycle, Cori Cycle, Ketone Bodies

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 2342
• Professor: Keir J Menzies

Document Summary

Chapter 8 central role of the liber in metabolism (find slides (chapter 7 and 8 with these diagrams) Fatty acid metabolism in the liver: why ketones and not tca cycle, fasted state increases gluconeogenesis: uses up all available oxaloacetate (start of tca cycle) for making glucose, so tca is not possible. If (cid:449)e"re lo(cid:449) o(cid:374) glucose or gl(cid:455)coge(cid:374) the(cid:374) (cid:449)e do(cid:374)"t ha(cid:448)e e(cid:374)ough o(cid:454)alate (cid:894)(cid:449)t(cid:448) its called(cid:895) for the tca c(cid:455)cle thus forming ketone bodies in the blood. In fed state: gut also makes a version of vldl (no need to remember) In the liver: glycogen synthesis, glycolysis, gluconeogenesis, fatty acid and triglyceride synthesis, protein synthesis. In adipose tissue: glucose transport into adipose, glycolysis, fatty acid and triglyceride synthesis, triglyceride degradation. Also knows that it will run out of fat so instead of calling it over fro(cid:373) so(cid:373)e(cid:449)here the lipids are i(cid:374)ter(cid:373)uscular so the(cid:455)"re readily available. In the liver: glycogen degradation, gluconeogenesis, fatty acid oxidation, ketone body synthesis.