HSS 2305 Lecture Notes - Lecture 5: Hyaline Cartilage, Basement Membrane, Extracellular Matrix

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 2305
• Professor: Keir J Menzies

Document Summary

2: most cells know when to stop growing, cancer cells do(cid:374)"t k(cid:374)ow whe(cid:374) to stop fro(cid:373) outside signals. Immunoglobulins: polypeptide chains organized into a folded structure. Immunoglobulin superfamily (igsf) most involved in aspects of immune function. Cadherins: family of glycoporteins that mediate calcium-dependent cell-cell adhesion. Andchoring junctions: adherens junctions ells held together by ca dependent cadherin clusters, common in epithelia as a band around the cell, catenin-actin intracellular interactions and signaling. 3: desmosomes disk shaped adhesive junctions (~1um), in tissues with mechanical stress acts as one of the stronger cell-to-cell adherens, contain non-classical cadherins desmogleins, desmocollins, plaque-keratin intracellular interactions and signaling. Cell-adhesion receptors all cell-ecm and cell-cell interactions can take part in transmembrane signaling: protein kinases phosphorylation; g proteins physical interaction, ph, ca2+, protein phosphorylation, gene expression. Ca2+ sharing of key metabolites btwn cells i. e atp: electrical impulse in cardiomycoytes electrical impulse sa node > spreads a current of ions through connexin43 (cx43) of neighbouring cardiomyocytes > synchronized contraction.