HSS 2305 Lecture Notes - Lecture 25: Tumor Suppressor Gene, Maturation Promoting Factor, Spindle Apparatus

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 2305
• Professor: Keir J Menzies

Document Summary

Proto-oncogene = gene that encode for proteins that stimulate cell division, inhibit cell differentiation, and halt cell death. Proto-oncogene + mutation = oncogene cancer: excessive cell division, inhibition of cell death. Tumor suppressor gene = gene that encode for proteins that slow down cell division, repair dna mistakes, or tell cells when to die. Tumor suppressor gene + mutation = dysfunctional tumor suppressor gene cancer: excessive cell proliferation, dna mistakes, inhibition of apoptosis. Series of stages in life cycle of cell m phase and interphase. M phase includes mitosis and cytokinesis: mitosis last ~ 1 hour. Interphase constitutes the majority of the cell cycle normal function and preparation for mitosis: may extend for days, weeks, or longer. 3 cell types based on their capacity to grow and divide. 1. highly specialized and lack the ability to divide: exist in g0, nerve cells, muscle cells, or red blood cells.