HSS 1101 Lecture Notes - Lecture 3: Antibiotic Misuse, Penicillin Binding Proteins, Antimicrobial Resistance
22 Jan 2017
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Document Summary
In human health the normal flora bacteria function as a balanced ecosystem with multiple species at a site and no single organism predominating. Organisms do not invade the body outside their normal territory. Infection with bacteria occurs when a single species becomes predominate at a site at which there is normally many species or when a single organism invades a body site that is normally sterile. When this occurs the outcome is determined by the bacterial pathogenicity factors and by the host response to those aggressive bacterial mechanism(s). The more important of these are as follows, and include mechanical barriers, adherence, phagocytosis, antibodies (humoural immunity), complement, cell mediated immunity and endo/exo-- to(cid:454)i(cid:374) produ(cid:272)tio(cid:374). The skin is a barrier to the invasion of deep tissues by bacteria. The skin is extensively colonized by large numbers of organisms that do not normally gain access to the deeper subcutaneous tissues.
