BPS 3102 Lecture Notes - Lecture 6: Cyp2D6, Cytochrome P450, Methadone
29 Jan 2016
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Possible explanation: nicotine in smoke is metabolized by cyp2d6 enzymes, drugs (opiates like methadone) are also using this enzyme. Patient was inhibiting/slowing the metabolism of methadone in the body. Quitting smoking, then methadone metabolism increases, leading to lower bioavailability. Actual: nicotine is an inducer of the enzyme; therefore, stopping smoking, enzyme is no longer induced and methadone bioavailability is at a higher than therapeutic level toxicity. 4 related interact with h-bond rich areas: cyp2c9: metabolizes weakly anionic and lipophilic compounds, and a specific isomer of warfarin (the s; r-warfarin is metabolized by a bunch of other cyp enzymes) Almost exclusively in liver, inducible and co-inducible. Different distribution of alleles across the globe; rapid, ultra-rapid and slow metabolizers. Cyp2c19: neutral or weak bases, moderate lipophilic (some of the substrate drugs have polar groups) habituated region: frequency of poor metabolizers varies with genetic background and.
