BPS 3102 Lecture Notes - Lecture 2: Pharmacokinetics, Bioavailability, Adme

• School: University of Ottawa
• Department: Biopharmaceutical sciences
• Course: BPS 3102
• Professor: Dr.Cory Harris

Document Summary

Pharmacology and toxicology developed from multiple roots; basic sciences, math, medicine, psychology, anthropology. In turn, subdisciplines have been created; studies about exposure, moa (pharmacokinetics, dynamics), system-specific effects, application or specific (forensic uses) Overall concepts: environment, substance person"s system effect elimination. How the organism affects the substance; determines the levels of the substance in the body, at critical sites various times after exposure. relation of the dose given to the amount present in the blood. Environmental, inhalation, oral, iv, im, it: exposure, absorption, distribution, metabolism, elimination. Adme underlines bioavailability; the rate and extent to which a substance is absorbed and is available at the site of action fraction of unchanged substance that reaches systemic circulation response generally related to concentration at soa. Properties of the organism, the substance are important. Pharmacodynamics the biochemical and physiological effect (and magnitude of that effect!) of substances on organisms.