BPS 3102 Lecture Notes - Lecture 1: Biotransformation, Blood Plasma, Pharmacodynamics

• School: University of Ottawa
• Department: Biopharmaceutical sciences
• Course: BPS 3102
• Professor: Cory Steven Harris

Document Summary

Pharmakos - human sacrifice to heal community problems caused by gods. In healing and in altering state of mind and body. Humours of blood, phlegm, black and yellow bile. Galen, wrote a bunch of stuff and added 4 more humours. Not much progress except distribution of galen"s books. Used a separate system, not the ebers papyrus. Substance = any chemical agent that affects living organism. Was a maverick and angry so he was ignored. Injection in animal can be found to travel across body. Also a bunch of terrible problems in gas releases, sarin, thalidomide, chernobyl. Speed of molecule as it goes through body. Fate and time course of substance in organisms. Determines bioavailability rate and extent to which a substance is absorbed by the organism and becomes available at the site of action (soa) Relative amount and rate of an administered dose/exposure reaching the systemic circulation. Can vary between nasal iv and oral and ways of entrance.