BPS 2110 Lecture Notes - Lecture 1: Pasteurization, Anticoagulant, Lisinopril

• School: University of Ottawa
• Department: Biopharmaceutical sciences
• Course: BPS 2110
• Professor: Robert Ben

Document Summary

Study of the properties of therapeutic substances and their dosages/bioactivity relationship. Dose and bioactivity are usually proportional: the larger the dose the greater the bioactivity. Dose/bioactivity relationship is really important: need to take enough but taking too much can be bad. This relationship needs to be monitored due to different metabolic pathways. Vaccines (and conjugates: attenuated vaccine: take pathogen a and attenuate it (make it less virulent) by heating it, denaturing it, removing protein coat, etc. If not done properly can cause someone to become infected. Immunocompromised people are even more vulnerable and can actually get sick due to pathogen. 5 - 6% of people who took the vaccine got polio due to a compromised immune system. Tend not to be used very much. Surface marker proteins: use unique identi ers of pathogens and use a protein scaffolding with the marker as the vaccine. Not regulated very well, can cause problems.