BPS 2110 Lecture Notes - Lecture 8: Pantothenic Acid, Acetyl-Coa, Lactone

• School: University of Ottawa
• Department: Biopharmaceutical sciences
• Course: BPS 2110
• Professor: Alain Musende

Document Summary

Many structures in this lecture, focus on the story and rational design, we will talk about biosynthesis, talk about how cholesterol is put together in our bodies. Took years to understand how lead compounds were working (how does biochemical and biosynthetic pathways work with chemicals?) the lead drug (cid:272)ould(cid:374)(cid:859)t go fu(cid:396)the(cid:396) because it had a high toxicity. Ethnopharmacology: the study of the use of plant-derived materials in traditional societies for the purposes of maintaining and improving health. 80% of the world population uses plant materials to treat health problems. Anything from indigestion to cancer or some diseased state. This makes sense, because most drugs we use originate from nature, or some chemical structure found from plant extracts. Combining random screening of natural product libraries and ethnopharmacology is a clever strategy. This entails going out and talking to traditional societies. Fo(cid:396) e(cid:454)a(cid:373)ple, 5(cid:1004)% of (cid:858)(cid:374)e(cid:449)(cid:859) anti-cancer drugs come from natural products.