BPS 1101 Lecture Notes - Lecture 8: Jean Nicot, Chewing Tobacco, Polyethylene Glycol

• School: University of Ottawa
• Department: Biopharmaceutical sciences
• Course: BPS 1101
• Professor: William Ogilvie

Document Summary

Tobacco is the most dangerous substance in the world. Tobacco kills 420 000 per year (north america) Jean nicot introduced tobacco to france: l"herbe nicotaine. Tobacco smoking in clubs: water pipes popular in eastern countries. Cigarettes originally rolled by hand: bonsack machine (rolling machine) reduced production costs. Cigarettes became dangerous: machine manufacturing reduced cost. Could afford to smoke a lot: flue curing reduced irritants in smoke and harshness of smoke. Early cigarette adds emphasized mildness : cigarettes now addictive, these two factors increase exposure to toxic substances. Late 1800"s: 80 cigarettes per year, did not inhale. Today: 10 000 cigarettes per year, inhale deeply, hold smoke in lungs. Nicotine is the addictive substance & smokers regulate the dose. 2 mg per cigarette required to addict smoker exactly what is delivered. Nicotine is an agonist at low doses sends messages without the normal messenger drug. Nicotine is an antagonist at high doses blocks chemical messages drug.