BPS 1101 Lecture Notes - Lecture 10: Carl Duisberg, Phenacetin, Cyclooxygenase

• School: University of Ottawa
• Department: Biopharmaceutical sciences
• Course: BPS 1101
• Professor: who

Document Summary

Experimening to ind a vermifuge: gave paient naphthalene, noiced fever reducion. Chemist at bayer: needed to dispose of 50 tons of aminophenol turned it into (phenacein) Anipyreic: does not inhibit prostaglandin (does not stop swelling) Liver toxicity side efect by creaing cytochrome p 450 (toxic metabolite) can be caused by foods like alcohol. Tylenol pm has an anihistamines called diphenylhydramine (make you sleepy) Someone placed cyanide in tylenol killing 8 people. Tylenol was then recalled and replaced the capsules called (caplets) Safety seals are now added to all otc meds. Generic acetaminophen: good for pain bad for liver. Stomach hcl producion is increased and mucus is producion is decreased. However in the full 18 months were four ime more likely to a heart atack (made them look bad) Fda found that it did increase the risk of heart atacks. Company got sued (10,000 lawsuits) and decided to take the drug of the market.