BPS 1101 Lecture Notes - Lecture 15: Animal Testing, Capsaicin, Antihistamine
24 Mar 2015
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The hardest part in making a drug is getting the drug in the blood stream. Drugs must survive it (natural penicillin is very sensible to acid) and be dissolvable in water. To survive the small intestine, the drugs must dissolve in water and survive enzymes. The drugs usually go in the blood stream through the intestine cells, which are oily. The thing is water and oil do not mix, but the drug must dissolve in both. The drug must not be very destroyable by the liver. Drugs must touch your molecules to work (agonist/antagonist). At very low concentrations, it will not chemically stick (low dose= dose makes the poison). There is a minimum dose needed to stick. Your must ensure that this e ective dose is lower than the amount after the barriers. Side e ects are due by the fact that the molecules do not stick to the right biological molecule.
