BCH 2333 Lecture Notes - Lecture 16: Phosphorylation, Homeostasis, Glycogen Phosphorylase
16 Dec 2017
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Document Summary
Control metabolic processes, respond to environment, etc: control the amount of enzyme available. Make more or less protein (transcriptional or translational control) Degrade more or less protein: control of enzyme activity. Allosteric control of enzyme activity: binding of an effector model changes enzyme function (mwc and knf) Allosteric regulators: positive regulators: atp, asp, cbmp (asp and cbmp are substrates) Increases reaction rate: negative regulator: ctp - downstream nal product. Activator/inhibitor cause change in enzyme activity at [s] kd. Controls the amount of product made by a relatively long pathway (~5-10 enzymes) The downstream product of the pathway ( nal product) is a negative regulator of the pathway. If there"s too much product, it will inhibit the pathway and the formation of more product. If there"s not enough product, there is not enough available to inhibit the pathway and production continues. Activator will bind preferentially to the r state. Inhibitor will bind preferentially to the t state.
