BCH 2333 Lecture Notes - Lecture 5: Cell Nucleus, Amine, Steric Effects

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Nucleic acids are polymers of nucleotides connected via phosphodiester bonds. Sugar: deoxyribose or ribose sugar that acts as a scaffold to hold the base: deoxyribose in dna, ribose in rna. Sugar and base connected with a glycosylic/glycosidic bond. The bond is always formed between the anomeric carbon of the sugar and an amine group on the base: anomeric carbon: carbon connected to 2 o"s or 1 o and 1 n, only has single bonds. Sugar: start with the anomeric carbon as 1. Base: amino group forming the bond is 1 for pyrimidines and 9 for purines. When the sugar is added to the base and forms the nucleoside, the numbering stays the same but is now designated using the prime (ex. Deoxyribose: no oh group on the 2" carbon. Has three acids, each with their own pka. Triesters are never seen in biochemistry due to instability (especially in water) Phosphate at the 5" end of the sugar.

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