BCH 2333 Lecture Notes - Lecture 6: Newman Projection, Solvation Shell, Protein Folding
31 Jan 2017
School
Department
Course
Professor
Document Summary
Fully folded polypeptides that come together to interact. Proteins adopt a specific 3d conformation unlike most other organic polymers. Structure is what gives these molecules their function. This 3d structure is called the native fold. Native fold has many favorable interactions within the protein. Drives the initiation of protein folding in many cases wants to decrease water on hydrophobic areas/decrease solvation shell around hydrophobic groups. Hydrophobic side chains want to be buried on the inside of the protein. Stabilize things, very strong occur in backbone nh and =o occur between side chains as well. If you build up enough surfaces interacting, you can get a lot of stability out of this force because groups back closely together on interior of proteins. Packing density tells us how outside the proteins to attract others. Charged residues can interact if close together work packed they are. Locks it into place there is restricted rotation amide is planar.
