BCH 2333 Lecture Notes - Lecture 4: Arginine, Threonine, Tyrosine
26 Jan 2017
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Lecture 4 - henderson hasselbalch and amino acids. For amino acid pkas just know "ballpark" eg 6. Henderson hasselbalch equation ph = pka + log([a-]/[ha]) When adding base, you start remove the hydronium ions. Will shift towards product --> increase in conc of conj base and decrease in acid. Shift from left hand side to right hand side. In red square you have more ha than a- At intersection, you have the equilibrium, where ph = pka. At green both you have more a- than ha. **henderson hasselbalch equation describes the titration of all weak acids** If the ph of lactic acid is 5. 2, and the lactate concentration is 8mm, what is the concentration of lactic acid? (pka = 3. 86) ph = pka + log([a-]/[ha]) Should be able to solve this for midterm. Assalic acid succinic acid pka~1. 25, pka ~4. 2 pka"s differ by less than 1. 4. The pka"s of the two associated acid groups are not independent.
