BCH 2333 Lecture Notes - Lecture 3: Logarithmic Scale, Enthalpy, Acid Dissociation Constant
26 Jan 2017
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Eg describe the main driving force for hydrophobic collapse with gibbs free energy. Know the seven side amino acid chains that will be protonated or deprotonated and at what ph. Amino acids pka yes, but mostly the ph. Will need to know how to derive henderson hassle back equation. Gibbs = -rtlnkeq, if <0 keq > 1, favour folded state, if >0 keq<1 favours unfolded state deltagibbs = delta h - tdeltas. Delta h = enthalpy = heat = q. = sum of bond energy broken - sum of bond energy formed. Forming bonds in a folded state greater than in the unfolded state. Must consider the bulk water around the protein. Clathrate cage around unfolded protein, the non-polar unfolded protein. Ordered layer around protein, the ordered water prefers to be disordered. Water does not like being around the protein, would rather be surrounded by other water molecules.
