ANP 1107 Lecture Notes - Lecture 13: Phagocytosis, Immunoglobulin M, Fetus

• School: University of Ottawa
• Department: Anatomy and Physiology
• Course: ANP 1107
• Professor: Jackie Carnegie

Document Summary

3 crucial cell types involved in body immunity: b lymphocytes - humeral immunity; antibodies are released in tissues to bind to foreign substances, macrophages - antigen-presenting cells. Lymphocytes: originate in red bone marrow from hemocytoblasts, all lymphocytes are initially identical, they become b or t depending on where in the body it acquires immunocompetence. T cells acquire immunocompetence in the thalamus gland; b cells acquire immunocompetence in the bone marrow. Major histocompatibility complex: markers on the surface on the cell that identify the cell and tissues (i. e allow identification of muscle cell and cell of the body vs. antigen) Antigen: t-cells migrate to thymus where it undergoes maturation (2-3 days) under direction of thymic hormones. Positive selection t cells must recognize self-mhc (on antigen-presenting thymic cell) Failure to recognize (bind tightly to) self-antigen results in survival and continued maturation: a(cid:374)ti(cid:271)odies (cid:272)a(cid:374) ha(cid:374)dle o(cid:374)ly o(cid:271)(cid:448)ious a(cid:374)tige(cid:374)s (cid:894)outside (cid:272)ells(cid:895); (cid:272)a(cid:374)"t fight tb (cid:271)a(cid:272)illus or (cid:448)iruses that (cid:373)ultiply inside cell.