ANP 1107 Lecture Notes - Lecture 4: Gastric Mucosa, Helicobacter Pylori, Gastric Glands

• School: University of Ottawa
• Department: Anatomy and Physiology
• Course: ANP 1107
• Professor: Jackie Carnegie

Document Summary

Physiology of the gi system: digestive functions of the stomach and their regulation. The stomach is a temporary storage tank where the chemical breakdown of proteins begins, converting food to chyme. Mechanical digestion via the churning action of the stomach and propulsion. Protein digestion occurs through one type of signi cant enzymatic digestion, primarily via the action of pepsin. Lipid-soluble drugs (alcohol and aspirin) are easily absorbed by the stomach mucosa. The only stomach function essential to life is the production of the intrinsic factor. Secretion of hcl facilitates the reduction of food particles into chyme, denatures proteins and nucleic acid, and transforms inactive pepsinogen into pepsin and destroys bacteria. Under normal conditions, the gastric mucosa secretes up to 2-3l of gastric juice each day. Stimuli acting at three distinct sites: the head, the stomach, and the small intestine, provoke or inhibit gastric secretions.