ANP 1105 Lecture Notes - Lecture 1: Platelet-Derived Growth Factor, Vascular Endothelial Growth Factor, Growth Factor

• School: University of Ottawa
• Department: Anatomy and Physiology
• Course: ANP 1105
• Professor: William Staines

Document Summary

You have bits of the cells pinching off. As with most cells of the cardiovascular system, they are short lived. They are anucleate, so if they are damaged they can"t fix themselves. They are regulated by thrombopoitin. (erythropoietin regulates red blood cells) Hemostasis (stop blood: you get some sort of injury, this process kicks in. Vasoconstriction (to slow down blood flow in that area). It causes platelets to come to that area: platelet plugs: all the platlets come together in that one area and start a clot. The endothelial cells on the lining of the blood vessel inhibit platelets sticking together. Only when you need a clot the platlets will stick together. They will stick together where there is roughend areas (where the blood vessel is broken). This starts the degranulation (they carry around adp, serotonin, thromoboxane a2) When the platlets are activated they change structurally and get spikey things, to enhance the sticking process.