HLSC 4310U Lecture Notes - Lecture 2: Adrenergic Receptor, Bronchiole, Catecholamine
Document Summary
Respond to a neurotransmitter, or endogenous signalling molecule. Composed by long sequences of amino acids: hundreds of them. Body has dozen of receptor types to maintain communication and must be differentiated from each other. Each cell may have many receptors depending on age health and other factors. B1 selective drugs would only affect the heart. smooth muscles and dilate bronchioles for breathing. Subtypes amino acid sequence differs in the receptors. Asthma treatment b2 selective drugs activate lung adrenoreceptors to relax bind to particular receptor selectivity. Affinity form complex with receptor: key enters hole of lock affinity. Receptor is analogous to a lock and ligand is a key. Only those drugs with a proper shape and size and physical properties can: how well the drug and the receptor recognize each other, binds to particular drug compared to other molecules. Drug concentration is measured in milligrams or millimole. S shaped: minimum concentration od drug required to achieve response.
