HLSC 3463U Lecture 5: Genes to proteins
19 Sep 2019
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Lecture 5: human gene expression genes to proteins. Inborn error of metabolism are hereditary and that traits are controlled by biochemical pathways that are controlled by enzymes. We need phenylalanine to break down into tyrosine to build our own polypeptides, such as melanin. If there is no enzyme to break homogentisic acid down, it needs to be excreted. The acid can build up and be toxic to the child. Pku and other disorders of the metabolic pathways of phenylalanine. Phenylalanine can be converted to pyruvic acid. Basically everything that we eat contains phenylalanine. Tyrosine is needed to make melanine and other catecholamines (epinephrine and norepinephrine) Tyrosine controls everything in your brain by producing dopamine. As soon as we have two carriers of the disease that mate, there is a . In pku, phenylpyruvic acid is the toxin that is accumulating. chance in inheriting pku. Single nucleotide transfer/change incredible profound effect. Conversion of phenylalanine to a toxic acid.
