BIOL 1010U Lecture Notes - Lecture 18: Human Height, Personalized Medicine, Major Depressive Disorder
Document Summary
Genetic and environmental basis of complex traits lecture. Textbook reference: chapter 18 in biology how life works (2nd ed. ) Influences by multiple genes + the environment: complex traits are much more prevalent than single gene traits. For example: high blood pressure, obesity, diabetes, depression, quantitative traits vs. single-gene traits: Complex traits and environmental influence: expression of complex traits is susceptible to what factors, lifestyle choices and other environmental factors, examples: Inadequate nutrition is linked to slow growth: salt intake is associated with an increased likelihood of high blood pressure. Mendel worked out for single-gene traits, but that the inheritance patterns are more difficult to see because of the number of genes involved. 2: number of genes and alleles involved: three unlinked genes, with two alleles, normal distribution bar graph that approximated a bell-shaped curve, the phenotype of many complex traits, conform to a normal distribution.
