BIOL 1010U Lecture Notes - Interleukin 10, Natural Killer Cell, Immunoglobulin Class Switching
Document Summary
Cd4 t-helper cell effector functions antigen recognition does not occur at site of entry, but usually in lymph nodes/spleen activated t cells then migrate to target tissues. Il2r complex of that associate non-covalently essential for immune function, as its chains are involved in many ilr"s. Il7 growth factor for immature t cells (cd4-, cd8-) in thymus produced by thymus stromal cells. Th1 synthesize il2/3, tnf , -interferon activates macrophages and enhances their ability to kill ingested microbes (bacteria, fungi, protozoa: -inteferon is released in response to macrophage mhc ii antigen presentation, cd40 (macrophage) binds cd40l(t cell) and/or. Tnf (t cell) interacts with tnf-r (macrophage) these combined enhance macrophage lysosome-phagosome fusion enhanced macrophage ability is now independent of antigen. Dth delayed type hypersensitivity can be used to determine immune status (tb skin test- ppd) Inflammation results from local accumulation of macrophages. Occurs in response to antigen-activation of th1 cells that are already sensitized to the specific antigen.
